Anticonvulsants : SAR of Anticonvulsants, mechanism of anticonvulsant action Barbiturates : Phenobarbitone, Methabarbital. Beta amino ketones : Molindone hydrochloride. Fluro buterophenones : Haloperidol, Droperidol, Risperidone. Ring Analogues of Phenothiazeines : Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Antipsychotics Phenothiazeines : SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Decode A Guide for Engineering Students (v) Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Aldehyde and their derivatives : Triclofos sodium, Paraldehyde. Alcohol and their carbamate derivatives: Meprobomate, Ethchlorvynol. Sedatives and Hypnotics : Benzodiazepines : SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem Barbiturates : SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital Miscelleneous : Amides and imides : Glutethmide. (Chapter - 3) UNIT - IV : Drugs acting on Central Nervous System A. Synthetic cholinergic blocking agents : Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride. Cholinergic Blocking agents : SAR of cholinolytic agents Solanaceous alkaloids and analogues : Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*. Cholinesterase reactivator : Pralidoxime chloride. Indirect acting/Cholinesterase inhibitors (Reversible & Irreversible) : Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion. Parasympathomimetic agents : SAR of Parasympathomimetic agents Direct acting agents : Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
Cholinergic receptors (Muscarinic & Nicotinic) and their distribution. (Chapter - 2) Decode A Guide for Engineering Students (iv) UNIT - III : Cholinergic Neurotransmitters : Biosynthesis and catabolism of acetylcholine.
Beta adrenergic blockers : SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol. Adrenergic Antagonists : Alpha adrenergic blockers : Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide. Agents with mixed mechanism : Ephedrine, Metaraminol. Indirect acting agents : Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine. Sympathomimetic agents: SAR of Sympathomimetic agents Direct acting : Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
Adrenergic receptors (Alpha & Beta) and their distribution.
(Chapter - 1) UNIT - II : Drugs Acting on Autonomic Nervous System Adrenergic Neurotransmitters : Biosynthesis and catabolism of catecholamine. Factors affecting drug metabolism including stereo chemical aspects. Drug metabolism : Drug metabolism principles- Phase I and Phase II. Course Content Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*) UNIT - I : Introduction to Medicinal Chemistry History and development of medicinal chemistry Physicochemical properties in relation to biological action : Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism.
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